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The pathogenetic role of oxidative stress in NALFD is well known and would explain the rationale for the use of GSH as a potential therapy

One caveat of these studies is that many NSAIDs do not require a prescription and are one of the most commonly used over the counter medications

The most frequent cause of SLOCA is multiple system atrophy, a rapidly progressive neurodegenerative condition that combines cerebellar ataxia, dysautonomia (typically genitourinary impairment or orthostatic hypotension) and parkinsonism