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The SURMOUNT-5 trial, published in The New England Journal of Medicine , directly compared tirzepatide to semaglutide and found tirzepatide produced 47% greater relative weight loss at 72 weeks, 20.2% of body weight versus 13.7%

This diet alters gut microbiota profiles, such as higher population levels of Clostridium cluster XIVa, Lactobacilli, and Bifidobacteria, and lower levels of Firmicutes and Proteobacteria

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