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Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma

Sattar et al., 2021)

It causes an immediate release of almost all the granules (containing serotonin, histamine, chemokines, cytokines, enzymes, heparin, and prostaglandins), which trigger itching, swelling, mucous, and anaphylaxis.[ref] A delayed response by mast cells comes from the formation of other mediators, such as prostaglandin D2

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RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells