This release of histamine and tryptase increases blood flow to the skeletal muscles during exercise.[ref] Hypoxia has also been shown to induce mast cell degranulation.[ref] This is a normal response for most people, and the body can handle a certain increase in histamine and tryptase
The vitrification process leads to mitochondrial dysfunction, characterized by a reduction in mitochondrial membrane potential (MMP), an increase in ROS, and elevated mitochondrial Ca 2+ levels (44), ultimately resulting in oocyte apoptosis and diminished developmental potential (45)
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This is by Vasireddi et al., so theres a bunch of different authors
NFB then triggers other cells to release cytokines