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Research on semaglutide discontinuation shows that weight regain occurs in the majority of users who stop treatment, which means that the nutritional challenges of GLP-1 therapy may persist for years

A B12 shot can rapidly restore energy and appetite in people who were deficient, which sometimes leads to weight gain as health returns

Further longitudinal studies are required to clarify causality in what appears to be a bidirectional relationship, particularly since T2DM and sarcopenia share common risk factors including low physical activity, malnutrition, inflammation, mitochondrial dysfunction [25,26]

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