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Side Effects Each drug has a distinct side effect profile to know: Phentermine: dry mouth, insomnia, constipation, irritability, increased heart rate and blood pressure (remember, it's a sympathomimetic) Lorcaserin: headache, dizziness, fatigue, nausea, constipation Naltrexone/Bupropion: nausea (most common, especially early in treatment), constipation, headache, vomiting, dizziness Drug Interactions These interactions are high-yield for exams and clinical safety: Phentermine With MAOIs: risk of hypertensive crisis

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