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NHS guidance describes an initial phase that can be every other day for 2 weeks (or until symptoms improve).Maintenance schedules are often every 23 months in appropriate long-term cases

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159 SIRT1 alleviates ER stress by deacetylating molecules such as eIF2 and CHOP, 32 inhibiting excessive activation of the unfolded protein response, 160 and reducing expression of stress-related proteins including GRP78 and ATF4

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