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Patients with personal thyroid history, family history of medullary thyroid carcinoma, or multiple endocrine neoplasia should avoid semaglutide entirely and explore alternative treatments with their provider

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273 Furthermore, a study using the anterior cruciate ligament transection (ACLT) rat model further confirmed that subcutaneous injection of liraglutide at 50 g/kg/day, whether for 3 weeks or 6 weeks, could reduce OARSI scores, highlighting the potential of liraglutide in treating joint degeneration