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The atherosclerosis mouse model was was induced as follows: ApoE / mice were fed a high-fat diet for 12 weeks, and the successful establishment of the AS model was confirmed by isolating arteries for ORO staining

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In contrast to human tissue and cultured cells, it has been demonstrated that Nrf2 activity is consistently elevated in the spinal cord of SOD1 G93A rodent models of ALS, and the increase of Nrf2, thioredoxin, HSP-70, HO1, NQO1, GCLC, and GCLM protein levels follows disease progression in the lumbar spinal cord but not cortex [264, 265]

J Biol Chem 293:6259

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