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Additionally, the elderly population may have decreased absorption or utilization of dietary vitamin B6, making supplementation a viable option

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Metabolic Effects and Hypoglycemia Risk As an insulin-like peptide, IGF-1 DES can lower blood glucose through enhanced glucose uptake, insulin-mimetic effects, improved insulin sensitivity, but risk of hypoglycemia at high doses

Since your body cant make its vitamin B12, you need to get it from external sources