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Patients frequently describe a profound, crushing fatigue that does not improve with rest, accompanied by a thick, disorienting cognitive impairment commonly referred to as "brain fog." For those living with these invisible illnesses, the frustration of navigating a medical system that often lacks clear answers can be just as exhausting as the physical symptoms themselves

Methods The current placebo-controlled double-blind randomized clinical trial was performed on 46 women with obesity, randomly allocated to either concomitant supplementation [L-carnitine tartrate (2 500 mg/day) + multistrain/multispecies synbiotic (1 capsule/day)] or monotherapy [L-carnitine tartrate (2 500 mg/day) + maltodextrin (1 capsule/day)] groups for 8 weeks

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Oral pigmentations may range from light brown to blue-black, red, or purple

This is because up to 25% or more of the energy produced through oxidative-phosphorylation is lost as reactive oxygen species (ROS), or free radicals