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A similar scenario has in fact been reported recently in an alcoholic liver disease model in which long-term alcohol consumption activated NF-B in Kupffer cells, whereas NF-B activation in hepatocytes was inhibited 45

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Clarke JD, Hsu A, Williams DE, Dashwood RH, Stevens JF, Yamamoto M, et al

This distinction helps explain why it progressed into formal obesity trials, whereas the raw fragment itself did not