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However, as gallbladder disease is not an issue with sodium-glucose co-transporter-2 (SGLT-2) inhibitors (with similar weight loss) (89), and gallbladder events also occurred in GLP-1RA-treated patients well after weight reduction (90), other mechanisms are possibly in play

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Anecdotal reports from patients taking GLP-1 receptor agonists have occasionally mentioned changes in sexual desire, but these accounts are not substantiated by robust clinical evidence and causality remains unproven