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How This Works FOXO4-DRI is a synthetic peptide that selectively targets senescent cells by blocking the FOXO4p53 protein interaction [1] [2]

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In vitro studies with human hepatocytes showed that phenytoin and phenobarbital inhibit acetaminophen glucuronidation, suggesting that other pathways of the drug metabolism, like oxidation to toxic NAPQI, may be potentiated [17,18]

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[DOI] [PubMed] [Google Scholar] 175.Mitchell S.F., Lorsch J.R