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Take one capsule daily for the course of 90 days

Overall, the effectiveness of metformin was compromised by the disruption caused by antibiotics, highlighting the essential role of metformin-modulated microbiota in counteracting intestinal ferroptosis

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Through integrated proteomic and metabolomic analyses, we identified a high-inflammation, high-oxidation, low-metabolism triad in the hippocampus of CLP-induced SAE mice, providing novel insights into mechanisms underlying persistent cognitive deficits in SAE survivors