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Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice

Start with 50-100 mg IV hydrocortisone Q6hr (depending on severity)

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Unlike oral semaglutide, which still requires fasting administration and SNAC to enable gastric uptake, orforglipron is absorbed without specific timing restrictions, offering practical advantages for adherence