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The extrinsic pathway is initiated by the binding of proapoptotic ligands to death receptors on the cell surface, leading to the formation of the death-inducing signaling complex (DISC) and the activation of caspases (Qiao et al., 2024)

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Additionally, ALA was well-tolerated throughout the studies, leading to a favorable dose-dependent safety profile (Table 3)

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Real weight loss typically begins at the 5mg to 7.5mg range and accelerates as you titrate higher