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At higher dosages, it also participated in the modulation of AMPA-glutamate binding

In our study, blood glucose and insulin resistance started to increase with niacin doses over 500 mg/day

This last version is the only one that has ever been licenced for human use, although its use is now discontinued

However, with advancing age, mitochondria dysfunction and a deteriorating energy metabolism lead to reduced overall energy production and impaired mitochondrial quality control (MQC)

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