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Critically it provided the first evidence of the 'posttranslational processing of a polypeptide precursor into the mature functional form of the hormone by specialized proteolytic enzymes'

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For example: Semaglutide (Ozempic) is FDA-approved to reduce the risk of major adverse cardiovascular events in type 2 diabetes patients with established cardiovascular disease

Efficacy and Safety of Liraglutide Versus Sitagliptin, Both in Combination With Metformin, in Chinese Patients With Type 2 Diabetes: A 26-Week, Open-Label, Randomized, Active Comparator Clinical Trial