PubMed Chang CH, Tsai WC, Lin MS, et al
Patients with diabetes should discuss medication adjustments with their healthcare provider and monitor blood glucose levels, particularly when starting or increasing their Wegovy dose
In these trials, data on renal outcomes were also collected (Table 1), although not all trials had this as a prespecified outcome, and therefore the data should be interpreted with caution
Results are expected 20272028 and will be critical for NHS NICE appraisal and reimbursement decisions
Further analysis indicated that among the 19 overgrown bacterial families, 12 possessed the urease gene ( Alteromonadaceae , Clostridiaceae , Cellulomonadaceae , Enterobacteriaceae , Dermabacteraceae , Halomonadaceae , Micrococcaceae , Moraxellaceae , Methylococcaceae , Pseudomonadaceae , Polyangiaceae , and Xanthomonadaceae ), 5 harbored the uricase gene ( Dermabacteraceae , Cellulomonadaceae , Xanthomonadaceae , Micrococcaceae , and Polyangiaceae ) producing ammonia that is harmful to the intestinal epithelium, and 3 expressed the tryptophanase gene necessary for the conversion of tryptophan into indole, which is then metabolized by the liver into uremic toxins ( Enterobacteriaceae , Clostridiaceae , and Verrucomicrobiaceae ) (Wong et al., 2014)