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3 RGN-259 Phase 3 Trial in Neurotrophic Keratopathy Sosne et al., International Journal of Molecular Sciences (2022) This Phase 3 randomized, placebo-controlled, double-masked clinical trial evaluated topical 0.1% RGN-259 (full-length recombinant T4 ophthalmic solution) in patients with neurotrophic keratopathy

About this article Cite this article Oft, H.C., Simon, D.W

Human clinical studies report measurable reductions in HbA1c levels, body-weightrelated endpoints, and improved insulin sensitivity markers compared to placebo-controlled groups

The translational value of targeting cuproptosis and copper metabolism lies in the identification of key regulatory molecules (e.g., FDX1, DLAT, ATP7A/B) and potential biomarkers (e.g., serum CP and NCC) that could guide clinical decision-making

Omega-3 fatty acids (2-4g daily) support cardiovascular health during metabolic changes and may enhance insulin sensitivity