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The modulatory effect of lithium on doxorubicin-induced cardiotoxicity in rat

Standard titration schedule The established titration protocol, based on clinical trials including the landmark STEP 1 study, follows this progression

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While exact mechanisms remain somewhat unclear, one theory is that ultraviolet light increases plasmin activity in keratinocytes, which leads to an increase in melanocytic-stimulating mediators, such as arachidonic acid and -melanocyte stimulating hormone

doi: 10.1038/ni.3808 296 NaffaaMERosenbergVWatadATiosanoSYavneYChodickGet al