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Diabetes Control and Complications Trial

NSAIDs and Stomach Irritation Other NSAIDs, such as naproxen or aspirin, can irritate the stomach lining

GLP-1 receptor agonists, as a drug class, have been in clinical use since 2005, and semaglutide has been licensed since 2017

Common early effects include: Lower fasting blood glucose readings Reduced post-meal glucose spikes Decreased appetite, particularly for sweet or carbohydrate-rich foods Smaller portion sizes feel satisfying A noticeable quieting of intrusive thoughts about food Visible weight loss, when it occurs, takes longer than the glycemic effects