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1982 ( Clinical Orthopaedics and Related Research 171:264-272, PMID 7140077), direct electric currents ranging from 10 microA to 1000 microA increased ATP concentrations in rat skin tissue, with peak ATP production reported at 500 microamps and decline above that threshold per secondary literature analysis

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Tretinoin also plays a role in the drainage and expulsion of excess sebum and acne-contributing bacteria

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