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An imbalance between cellular oxidative and antioxidant systems, along with accumulation of oxidative damage and downregulation of Bcl2, can reduce the anti-apoptotic capacity of melanocytes, ultimately leading to hair greying [162]

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El-Khamisy SF, Masutani M, Suzuki H, Caldecott KW (2003) A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage