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For joint discomfort, adjustments to the dosage under clinical supervision usually resolve the issue

These sensations are usually part of the body adapting to metabolic changes, rather than a sign of serious issues

PMID 20463410

Increase in lifetime adverse drug reactions, service utilization, and disease severity among patients who will start COX-2 specific inhibitors: quantitative assessment of channeling bias and confounding by indication in 6689 patients with rheumatoid arthritis and osteoarthritis

Temperature sensitivity attributed to metabolic adjustment usually resolves within 24 weeks as your body adapts