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Muscle Tissue Preservation: Investigating the muscle-sparing effects of NNMT inhibition during periods of significant fat oxidation

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Under oxidative conditions, SIRT1 expression is upregulated as a compensatory response, and its activity is further enhanced by compounds like celastrol and melatonin, which reduce the levels and activaion of H2AX, XRCC6, and PARP1 84,85