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Semaglutide is not recommended during pregnancy, and contraception should be discussed with the prescribing physician

Medicines regulators in numerous countries (e.g., the Therapeutic Goods Administration (TGA) in Australia) issued warnings of semaglutide shortages, which the TGA attributed directly to off-label prescription driven by viral TikTok videos about achieving rapid weight loss with Ozempic [43, 56]

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It has minimal activity at MC3R, MC4R, and MC5R compared to MT2

As demand for semaglutide drugs has doubled since 2021, the FDA is now warning that compounded versions mixed and tailored by a pharmacist but not manufactured by a name-brand company could cause adverse and dangerous side effects