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Since DmGSTS1-1 was highly expressed in the flight muscle, the localization of the corresponding GST enzyme might provide a protective role against oxidative stress generated from mitochondrial respiration [128]

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Why it matters: This is rare, peptides usually break down in the stomach

DIO: diet-induced obesity

Initially, main concerns were receptor-activating activity while recently, downstream effects of GLP-1R and GIPR have been more and more revealed that not only receptor activation promotes cAMP and stimulates insulin releasing, but also other factors (-arrestin recruitment, residence time, etc.) influence receptor internalization, which further elicits long-term effects in vivo