MT-II is a cyclic heptapeptide broadly activating MC1R, MC3R, and MC4R , simultaneously producing melanogenesis alongside central pro-sexual, pro-erectile, and anorectic effects through hypothalamic MC3R/MC4R activation, Cyclisation of the -MSH pharmacophore core is the primary structural determinant of this receptor subtype selectivity shift
identified specific point mutations in the paternal allele of MAGEL2 in four individuals with PWS, where weight gain was a prominent feature along with muscle weakness, developmental delays, and hypogonadism ( Kanber and colleagues described a patient with deletions in MKRN3, MAGEL2, and NDN, exhibiting only obesity, developmental delay, and a high pain threshold as the primary clinical criteria for PWS ( The SNORD116 cluster is crucial in the PWS phenotype
Additionally, IL-6 and IL-23 can drive Th 17 differentiation, with IL-17 recruiting neutrophils that infiltrate thyroid tissue, causing direct damage to follicular epithelial cells (Stadhouders et al., 2018)
I've seen it in large organizations where there's 150, 200 employees all the way up to 10,000 plus
Do you believe there is a link to all of this being due to this mutation
