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In a randomized controlled trial of 72 patients with type 2 diabetes and reduced heart rate variability, oral supplementation with 800 mg/day of lipoic acid for four months resulted in significant improvement in two out of four measures of heart rate variability compared to placebo (81)

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While fewer ORAC-specific studies exist for GHK-Cu compared to conventional antioxidant compounds, the available data suggests the peptides primary antioxidant contribution operates through indirect enzymatic upregulation rather than direct radical quenching

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