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Through our literature search, we identified 14 additional cases from 10 families, each with different homozygous IL2RA pathogenic variants

Clinical data shows sustained weight reduction when medication dosing aligns with individual metabolic profiles

In addition, some people eat and drink less while on these medications, which can lead to dehydration and reduced fiber intake, both of which may worsen constipation

Corticosteroids increase hepatic glucose production, reduce peripheral glucose uptake in muscle and adipose tissue, and impair insulin secretion from pancreatic beta cells

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