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The second position of its N-terminus is glycine (alanine in GLP-1), which is not easily degraded by the DPP-4 enzyme.77 Compared with GLP-1, the C-terminus of its amino acid sequence contains 9 additional amino acid residues (PSSGAPPPS), which are not easily degraded by peptide chain endonucleases

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Weeks 13 through 16: 8 mg weekly What is happening: Full triple-agonist effects are now substantially engaged

The glucagon receptor component is thought to contribute to increased energy expenditure, though this too is based largely on early clinical and preclinical observations rather than definitive human data

This does not mean they cannot be combined, but it means researchers should be aware of the additive potential and monitor accordingly