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GSSG formation generates hydrogen peroxide as a byproduct, which further oxidizes remaining GSH in a self-reinforcing cycle

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396,397,398,399 GLP-1RAs and nerve cells GLP-1 can modulate peripheral nerves through the ERK (extracellular signal-regulated kinase) signaling pathway, reducing the occurrence of neurological dysfunction

Daley and colleagues revealed that hyperglycemia triggers Akt2 activation (phosphorylation) in RPE cells, which in turn increases the expression of EMT markers and fibrosis-related proteins via ERK signaling [6]

13 , 77.e177.e5 (2017)