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Probiotic and dietary interventions for the restoration of microbiota balance have shown promising results in animal models and initial human trials, with some signs of cognitive improvement and reduced inflammatory markers (Kang and Zivkovic, 2021

Glutamate is also needed for the production of glutathione

Psychiatry 10 , 421 (2020)

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To be specific, BRAF-targeted inhibitors would downregulate the expressions of sprouty RTK signaling antagonist 2/4 (SPRY2/4) and dual-specificity phosphatases (DUSPs), which leads to the relief of the feedback suppression on Ras and reactivation of the ERK signaling, thus rendering the treatment resistance