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Similarly, animal models that allow more head rotation after impact or enhanced head or brain movement produce more severe brain injuries (Foda and Marmarou, 1994

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This overstimulation results in increased intracellular calcium levels, leading to neuronal injury and apoptosis ( Postmortem examination of patients with chronic epilepsy reveals a noticeable atrophy of cerebellar Purkinje cells (Yardmoglu et al., 2007)