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A meta-analysis covering over 28,000 patients found that while the overall rate of GI adverse events was similar (approximately 5253% of patients in both groups), serious adverse events occurred somewhat more frequently with higher tirzepatide doses (5.37% at 1015 mg) compared to semaglutide (2.8%)

Additionally, healthcare providers should monitor their patients for signs of cancer while taking semaglutide

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2 It seems to achieve this by activating a network of neurons throughout the CNS, with many of these neurons being secondary targets that do not directly express GLP-1 receptors