why does semaglutide not work on some people for Weight Loss: How It Works, Comparisons, and More Why Semaglutide Isn't Working for

When serotonin levels are high, it can suppress appetite by creating a feeling of fullness or satiety

doi: 10.3390/antiox14080972 26 VassiliouEFarias-PereiraR

For a deeper dive into compound differences, see our Retatrutide vs Tirzepatide vs Semaglutide research comparison

Still requires exercise and a healthy diet Jamel Corona says she turned to Wegovy in 2021 after she couldnt lose weight on her own, despite a healthy lifestyle

In the SURMOUNT-5 head-to-head comparison with semaglutide, tirzepatide produced approximately 20% greater body weight reduction, establishing it as the more potent weight loss agent currently available.[5] PCOS-specific RCT data for tirzepatide is less mature than for semaglutide no large completed trials in PCOS populations exist as of early 2026 but the mechanistic case is compelling