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In the absence of published data, no stopping rules have been defined and it is recommended to treat these patients for a total of 48 weeks
That short activity window is part of why once-daily dosing is often used in educational referencesone consistent daily pulse can be enough to support a physiologic-style rhythm, especially when paired with steady sleep timing and nutrition consistency (since sleep, meal timing, and training load can all influence GH signaling day to day)
When going the subcutaneous route, so Wegovy or Ozempic, you can store a new and unopened injectable pen in the refrigerator
The detailed gradient conditions for LCMS analysis are shown in each figure legend in the Supplementary Figures