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Comparative analysis of structural properties When comparing the molecular structures of SLU-PP-332 and 5-amino-1mq, several key differences emerge: Size and complexity: SLU-PP-332 generally has a larger and more complex structure compared to 5-amino-1mq

Notably, the expression of Vegfa and Bmp4 was increased by 6.7-fold and 2.7-fold, respectively, in the HFD + Ret group compared to the HFD group

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Eight categories of psychiatric AEs were identified, including EDs, binge eating, fear of eating, and self-induced vomiting

Abbreviations CNRC: Childrens Nutrition Research Center FFM: Fat-free mass GIP: Gastric inhibitory polypeptide GLP-1: Glucagon-like peptide-1 GPR: Glucose production rate HISI: Hepatic insulin sensitivity index IGI: Insulinogenic index iGLP-1: Intact GLP-1 MIGHTY: Metformin Influences Gut Hormones in Youth NGT: Normal glucose tolerance NIH: National Institutes of Health PYY: Peptide YY R a : Rate of appearance WBISI: Whole-body insulin sensitivity index References Zeitler P, Hirst K, Pyle L et al (2012) A clinical trial to maintain glycemic control in youth with type 2 diabetes