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8.4 Transdermal and microneedle-assisted delivery Classical transdermal delivery is generally not suitable for macromolecules due to the stratum corneum barrier, which limits passive diffusion to molecules smaller than approximately 500 Da with appropriate lipophilicity

528 Excess irons can promote the progression of atherosclerosis by affecting macrophages, and a balanced intracellular iron environment is crucial in alleviating atherosclerosis

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In fact, many adults are completely unable to absorb B12 from oral ingestion