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Deficiency Insufficient selenium intake may negatively affect the activity of several selenium-responsive enzymes, including glutathione peroxidases (specifically, GPx1 and GPx3), iodothyronine deiodinases, selenoprotein W, and methionine-R-sulfoxide reductase B1 (MsrB1)

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For example, the popular diabetes drugs Victoza, also from Novo Nordisk, and Jardiance have been approved as treatments to reduce the risk of heart attack, stroke and death in heart patients

If these ROS overwhelm the cellular antioxidant response, cell death and tissue necrosis occurs, resulting in severe hepatotoxicity that can lead to death 6