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They cannot address severe structural abnormalities requiring surgery

The study participants were hypertensive (clinic systolic/diastolic BP of 140-179/90-109 mmHg and 24-hour ambulatory systolic/diastolic BP 130/80 mmHg) patients enrolled in a randomized controlled trial and treated with amlodipine 510 mg or nifedipine gastrointestinal therapeutic system (GITS) 3060 mg once daily

conditions like irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), or reflux could be at play