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At ASPN, tirzepatide is positioned as anadvanced metabolic signaling therapy, implemented selectively when dual-pathway incretin support is clinically appropriate and always within a long-term strategy focused on insulin sensitivity, metabolic signaling integrity, and sustainable outcomes

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Neurosci Lett 753:135870 Carvill GL, Liu A, Mandelstam S et al (2018) Severe infantile onset developmental and epileptic encephalopathy caused by mutations in autophagy gene WDR45 [J]