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Importantly, amitriptyline has been shown to increase suicidal thoughts in individuals under age 24 years

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It can be challenging to produce certain nanoparticles on a large scale for therapeutic applications due to their initial complex, expensive, and unreliable preparation procedure

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It modulates cell proliferation, survival, and metastasis through mechanisms like inhibiting DNA methyltransferases, regulating microRNA expression, and modulating key signaling molecules like NF-B and MAPK

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