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Tesofensine is a synthetic compound that acts as a potent triple monoamine reuptake inhibitor (TRI), primarily targeting the reuptake of dopamine, norepinephrine, and serotonin

The 15 mg strength is the highest licensed weekly maintenance dose

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estimate an overall incidence of DKA from SGLT2 inhibitor use of approximately 0.1%.[14] Data on a patient with type 1 diabetes who presented with DKA associated with SGLT2 inhibitors showed rates varying from 5% to 12%