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Administration is typically intranasal at 300 to 600 mcg once or twice daily, or subcutaneous at 300 to 500 mcg daily

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This regulatory effect of DMF was identified through NRF2-dependent and independent mechanisms with NRF2 binding to ARE motifs and increasing DNA 5hmC of individual gene regulatory regions involved in the TSS pathway, cystine uptake, and GSH generation

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