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The smallest dose of Leukine used for vaccine adjuvant purposes of which the applicant is aware (that is, 70 mcg) would lead to as much as 72 percent of the drug being discarded from a single-dose 250 mcg lyophilized vial, which is the only size available commercially

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According to StatPearls (NCBI Bookshelf), the most common adverse effect of intramuscular vitamin B12 injections is significant pain at the injection site, which is particularly noted in thinner individuals

Furthermore, RT-PCR and IHC findings confirmed that AST effectively reduced demyelination and oligodendrocyte loss in MS (Lotfi et al., 2021)