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The NAD + -to-NADH and ATP-to-ADP ratios were calculated from the peak area values of each metabolite within the same individual sample and compared between groups

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Studies have highlighted the role of persistent fibrosis in aged tissues, where myofibroblasts in injured tissues of aged mice acquire a sustained senescent and apoptosisresistant phenotype, exacerbating fibrosis (Hecker et al ., 2014)

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