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The analytic method was used as a first step in order to develop later our strategy and model for the development of these areas

, 475 , 1037-1057, Acknowledgments I express sincere appreciation to Lutz Schomburg and Kamil Demircan for critical comments and fruitful discussion

High Affinity, Low Concentration : Many endogenous hormones, like Thyrotropin-releasing hormone or Gonadotropin-releasing hormone, are secreted in picomolar to nanomolar quantities

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